Prevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites
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American Society for Microbiology
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10.1128/aac.01576-16
Abstract
A collection of 74 Enterobacteriaceae isolates found in Bo, Sierra Leone, were tested for quinolone antibiotic susceptibility and resistance mechanisms. The majority of isolates (62%) were resistant to quinolones, and 61% harbored chromosomal gyrA and/or parC mutations. Plasmid-mediated quinolone resistance genes were ubiquitous, with qnrB and aac(6')-Ib-cr being the most prevalent. Mutated LexA binding sites were found in all qnrB1 genes, and truncated qnrB pseudogenes were found in the majority of Citrobacter isolates.
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Łęski, T. A., Stockelman, M. G., Bangura, U., Chae, D., Ansumana, R., Stenger, D. A., Vora, G. J., & Taitt, C. R. (2016). Prevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites. Antimicrobial Agents and Chemotherapy, 60(11), 6920–6923. https://doi.org/10.1128/aac.01576-16
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Metadata only. Full text is not deposited in this repository; it is available from the publisher: https://doi.org/10.1128/aac.01576-16 (free to read, no open licence)