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Prevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites

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dc.contributor.authorŁęski, Tomasz A.
dc.date.accessioned2026-10-19T22:22:25Z
dc.date.issued2016-08-30
dc.description.abstractA collection of 74 Enterobacteriaceae isolates found in Bo, Sierra Leone, were tested for quinolone antibiotic susceptibility and resistance mechanisms. The majority of isolates (62%) were resistant to quinolones, and 61% harbored chromosomal gyrA and/or parC mutations. Plasmid-mediated quinolone resistance genes were ubiquitous, with qnrB and aac(6')-Ib-cr being the most prevalent. Mutated LexA binding sites were found in all qnrB1 genes, and truncated qnrB pseudogenes were found in the majority of Citrobacter isolates.
dc.identifier.citationŁęski, T. A., Stockelman, M. G., Bangura, U., Chae, D., Ansumana, R., Stenger, D. A., Vora, G. J., & Taitt, C. R. (2016). Prevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites. Antimicrobial Agents and Chemotherapy, 60(11), 6920–6923. https://doi.org/10.1128/aac.01576-16
dc.identifier.doi10.1128/aac.01576-16
dc.identifier.urihttps://doi.org/10.1128/aac.01576-16
dc.identifier.urihttps://dspace.njala.edu.sl/handle/20.500.144402/1247
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.relation.ispartofAntimicrobial Agents and Chemotherapy
dc.rightsMetadata only. Full text is not deposited in this repository; it is available from the publisher: https://doi.org/10.1128/aac.01576-16 (free to read, no open licence)
dc.subjectquinolone resistance
dc.titlePrevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites
dc.typeArticle

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